Simone's first casting for theatre was Arthur Miller and Michael Blakemore’s premiere of Miller's The Ride Down Mount Morgan for the Wyndham’s Theatre in 1991. She followed this with Desire for David Lan at the Almeida, Elegies for Angels, Punks and Raging Queens, Our Boys for Jonathan Lewis, Arthur Smith’s Sod for the Edinburgh Fringe and Twelve Angry Men for Harold Pinter. More recently she has co-cast Life is a Dream, The Scent of Roses, Red Ellen, Macbeth (an undoing) and Anna Karenina for the Lyceum Edinburgh and Dracula for the National Theatre of Scotland. She and Anna Dawson have recently completed casting on Macbeth for the RSC and are working on the new musical stage show, Restless Natives. As well as theatre, Simone casts films (including Munich: The Edge of War, Elizabeth, Hilary and Jackie and Hamlet) and television (including Outlander, Float and Granite Harbour).